Optimize Your Joint Health Daily^Footnote†

• Supports joint health and comfort^Footnote†
• Supports joint flexibility and function^Footnote†
• Features three patented joint health ingredients backed by more than a dozen human studies
• UC-II^® supplies undenatured type II collagen, which supports joint health and mobility by supporting healthy levels of collagen^Footnote†
• Mobilee^® extract is rich in hyaluronic acid, collagen, and glycosaminoglycans, which support joint mobility and function^Footnote†
• AprèsFlex^® Boswellia extract supports healthy joints and connective tissues^Footnote†
• All in just ONE small capsule you take just ONCE a day!

Key Benefits

60-Day Money Back Guarantee

Gluten Free & Soy Free

Dairy Free

Non GMO

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HEALTH BENEFITS
NUTRITION & INGREDIENTS
FAQs
HEALTH BENEFITS

What Happens to Joints as We Age?

Research shows over 40% of folks over the age of 40 are concerned or complain about their joints, and even more, it’s estimated that 80% or more of people who are 65 or older have some degree of joint wear and tear.

But even if it’s “normal,” it’s not “right.” After all, if your joints aren’t limber and healthy, that can limit your mobility, activity level, and independence and negatively impact your quality of life. Simply put, if your joints aren’t in tip-top shape, that can keep you from doing some of the things you love to do.

What exactly causes declining joint health?

Well, many of the same “negatives” that lead to other health problems can have a negative impact on your joints, including:

• Being overweight
• Getting older
• Not eating as well as you should
• Not being active enough and overusing/misusing joints

But what happens to joints as we age? Can a joint health supplement help?

Well, as we get older, there are three common factors that contribute to declining joint health and function:

1. The Collagen DECLINE

Collagen is the primary structural protein in cartilage—the spongy connective tissue that cushions the ends of your bones where your joints meet. Essentially, cartilage protects your bones from grinding against each other, bone on bone, which would be painful. As you age, however, less cushioning is available (particularly less type II joint collagen), leading to reduced joint comfort.^Footnote†

2. The DRY OUT

Hyaluronic acid is the chief component of joint fluid, also known as synovial fluid, which helps reduce the friction between bones by providing lubrication between cartilage. As cartilage decreases with age so do levels of hyaluronic acid and synovial fluid production, making it excessively difficult for joints to move freely—kind of like the hinges on a squeaky door.^Footnote†

3. The ATTACK of the Enzymes

Healthy levels of joint- and collagen-degrading enzymes, known as 5-LOX and MMPs, are important for normal, ongoing rebuilding of joint tissues. However, levels of 5-LOX and MMPs can grow in excess sometimes, which can cause collagen to decline even more.^Footnote†

In plain English, this means that people can experience joint discomfort when their joints aren’t getting the proper support they need—like the nutrients that form building blocks needed to support healthy levels of cartilage and proper lubrication in the joint.

The Problem with Most Joint Health Supplements

Unfortunately, the typical joint health supplement misses the mark, usually only addressing one of the joint health problems mentioned above. Even then, some joint health supplement ingredients are often marginally effective at best.

Take, for example, the most common joint health supplement ingredients: glucosamine and chondroitin. In one of the largest randomized controlled trials (GAIT), researchers randomly assigned 1,583 study participants to receive either glucosamine, chondroitin, both, an alternative intervention, or placebo for 24 weeks.^Footnote†

At the end of the 6-month study, the folks supplementing with glucosamine and chondroitin did NOT experience any greater improvements in joint function than the placebo group. In other words, the two popular joint health supplement ingredients glucosamine and chondroitin alone or in combination were not effective at improving joint health.

While that’s just one well-controlled study, a network meta-analysis (that analyzed the results of multiple studies) concluded that glucosamine, chondroitin and the two in combination did not relieve joint discomfort or improve joint health and function when compared with placebo.

Another big problem with other joint health supplements is that they often require taking many very LARGE capsules per day—often multiple times. Unfortunately, these are big hurdles to jump over as studies show that increased capsule size, capsule number, and frequency of taking capsules all negatively impact compliance, and if you can’t pop the right number of pills regularly, you can’t expect to reap the expected benefits of your joint health supplement.

What Makes Joint 33X the Right Choice for a Joint Health Supplement?

Thankfully, all hope is not lost. Just because many other joint health supplements miss the mark doesn’t mean we did too.

In fact, we developed a joint health supplement to address the three main factors to promote joint health and function, and we call it Joint 33X, a 3-in-1 joint health formula that features three patented, joint-nourishing ingredients that have been demonstrated to support joint health, mobility, flexibility, and function in more than a dozen human studies.^Footnote†

1. Support Healthy Levels of Collagen with UC-II^®

For starters, Joint 33X joint health supplement features UC-II^®, which provides a unique, highly effective form of undenatured type II collagen. Remember, collagen is the primary structural protein in connective tissues in the human body, including bones, cartilage, skin, and tendons, and it’s the wearing down of type II joint collagen that is associated with reduced joint health and function.

Four separate studies have tested the mettle of UC-II^®, which has been shown to support joint health and mobility by supporting healthy levels of collagen. Even more, UC-II^® has been shown to be more effective at improving joint flexibility and function than the popular joint health supplement ingredients glucosamine and chondroitin in head-to-head research.^Footnote†

2. Support Joint Comfort with Mobilee^®

The next all-star ingredient in Joint 33X joint health supplement is Mobilee^®, a natural hyaluronic acid matrix ingredient extracted from rooster comb containing a high concentration of hyaluronic acid, an important joint lubricant that decreases in quality and quantity with age.^Footnote†

Mobilee^® also provides other joint-nourishing compounds, including polysaccharides (e.g., glycosaminoglycans) and collagen. Thanks to the synergistic effect these three naturally-occurring components, Mobilee^® is a cutting-edge ingredient that provides support for joint comfort. The joint health benefits of Mobilee^® have been demonstrated in a half-dozen human studies.^Footnote†

3. Support Healthy Levels of Collagen Enzymes with AprèsFlex^®

Finally, Joint 33X joint health supplement features AprèsFlex^® Boswellia extract, which targets mediators (such as 5-LOX and MMPs) of comfort and flexibility. By supporting normal, healthy levels of these compounds, AprèsFlex^® supports healthy joints and connective tissues.^Footnote†

Two separate human studies have confirmed the potential of this next-generation Boswellia extract. Even more, research shows that study participants experience results they can feel as little as 5 days.^Footnote†

What’s more, Joint 33X joint health supplement provides support for results you can feel in less time than you might think with just ONE small capsule you take ONCE per day.

Simply put, we truly believe Joint 33X sets the bar as the best joint health supplement, and we’re confident that you’ll agree!

NUTRITION & INGREDIENTS

Joint 33X Nutrition & Ingredients

Joint 33X is an advanced 3-in-1 joint health supplement featuring three patented, joint-support ingredients that have been shown to support joint health, mobility, flexibility, and function in more than a dozen human studies.^† Unlike many joint health supplements, Joint 33X provides support that you can feel in less time than you might think with just ONE small capsule you take ONCE per day. Here are three key ingredients in Joint 33X:

• UC-II^® supplies undenatured type II collagen, which supports joint health and mobility by supporting healthy levels of collagen. UC-II has been shown to be more effective at improving joint flexibility and function than the popular joint supplement ingredients glucosamine and chondroitin in head-to-head research.^Footnote†
• Mobilee^® is a natural extract that is rich in hyaluronic acid, collagen, and glycosaminoglycans. Thanks to the synergistic effect these three naturally-occurring components, Mobilee^® is a cutting-edge ingredient that provides support for joint comfort.^Footnote†
• AprèsFlex^® Boswellia extract supports healthy joints and connective tissues by supporting normal, healthy levels of mediators of joint comfort and flexibility.^Footnote

FAQs

Q: What specifically makes Joint 33X the right choice?

Joint 33X is an advanced 3-in-1 joint health supplement that features THREE patented joint-support ingredients backed by more than a DOZEN human studies that address THREE main contributors to support joint health and mobility and joint flexibility and function. And you’ll be relieved to know that Joint 33X provides trusted joint support you can feel in as little 5 days. Perhaps best of all, all this joint-nourishing support comes in ONE small capsule you take just ONCE a day. Like all BioTRUST supplements, Joint 33X undergoes 3rd party testing to ensure purity, potency and safety.

Q: What is the best way to take this product?

Simply take one tiny capsule once a day without food.

Q: How long do I need to use this product before I see results?

The 3 joint health ingredients found in Joint 33X have been shown to work rapidly (within the first bottle). Having said that, research done on the individual ingredients found in this formula suggest additional improvements with regular use over time.

Q: Does this product contain caffeine or any other stimulants?

No. This product is caffeine- and stimulant-free.

Q: Are there any allergy concerns with this product?

This product is manufactured in a facility that also processes milk, eggs, fish, crustacean shellfish, tree nuts, peanuts and wheat. Always review the label for the most accurate information.

Q: If I have a medical condition, can I take this product?

Joint 33X is intended for use by healthy adults over 18 years old. Do not take this product if you are pregnant or nursing. If you are taking prescription or over-the-counter medications or being treated for any medical condition, please consult with your physician prior to supplementing. Discontinue use and consult your physician if you experience any adverse reaction to this product.

Q: What if this product doesn’t work for me?

While Joint 33X was created to work, if for any reason at all you are unsatisfied with your purchase, just send it back to us, and we will issue a prompt and courteous refund even on empty bottles. You’re always protected by our naturally-honest 60-Day Money Back Guarantee.

Ingredients

What’s in our Wellblends™ Back to Sleep™ Fast Dissolve Tablets

Amount Per Serving: 1 mg Melatonin, 100 mg L-theanine 100 mg, 100 mg GABA (Gamma-Aminobutyric Acid)

Item #HL000030

Nutrient Shortfalls

Where do we normally get this product from?

Melatonin is a hormone produced in the pineal gland in your brain that helps regulate the body’s natural sleep/wake cycle but is also present in very small amounts in some foods like tart cherries, pistachio nuts, rice, milk, eggs, salmon, and beef. L-theanine is a rare amino acid also found in some teas and the bay bolete mushroom. GABA is found throughout the body and acts as a neurotransmitter in the brain to help calm the mind. GABA is also found in some foods such as raw spinach, potatoes, and fermented foods, such as yogurt.[1]

Who might need to take this product?

Glad you asked! Nature Made® Wellblends™ Back To Sleep™ is a 3-in-1 blend powered by science.‡ You may want to consider Melatonin supplements for sleep if you have occasional difficulty falling asleep, staying asleep, or if you experience jet lag, or work night shifts. Nature Made® Wellblends™ Melatonin sleep aid solutions are scientifically designed with ingredients to support your rest, so shop now to find our best Melatonin supplement for you.†

Dosage & Interactions

Suggested Use

Adults, take 1 fast dissolve tablet 30 minutes before bedtime to help fall asleep or upon waking up in the middle of the night. Dissolve in mouth or chew before swallowing. No water necessary. Take at least 4 hours before waking.†

Interactions

No two people are alike, so if you are currently taking prescription medications, there may be potential drug-nutrient interactions. Consult a healthcare professional before using this product.

 Use Caution

Do not use this product, unless advised by a physician, if you are pregnant, attempting to become pregnant, nursing, taking any medications, or have any chronic medical conditions. Do not drive or operate machinery within four hours of taking this product or if you feel groggy. For occasional sleeplessness only; consult your physician if you continue to experience sleep difficulties or for use beyond three months. Not intended for individuals under the age of 18 years.

‡Ingredients powered by science

▲Not a low calorie food

◆Compared to Nature Made® Wellblends™ Melatonin products

* Based on a survey of pharmacists who recommend branded vitamins and supplements

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

1. Nutrients. Dietary Neurotransmitters: A Narrative Review on Current Knowledge. May 2018. Accessed on: January 18, 2024. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986471/1. Nutrients. Dietary Neurotransmitters: A Narrative Review on Current Knowledge. May 2018. Accessed on: January 18, 2024. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986471/

Real Stories by
Real People Like You

“Does the job for me at smaller melatonin dosage. I use it to go to sleep around bedtime and sometimes during the night. This has been my go to item.“

Verified Purchaser

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Questions?

See our frequently asked questions below:

How are Nature Made® Wellblends™ products different from other Nature Made® products?

Nature Made^® Wellblends™ is a premium line from Nature Made^® with blends powered by science^‡ to support your body’s health and wellness needs.^†

How does this product differ from your other sleep products?

Nature Made^® Wellblends™ Back To Sleep™ provides 3 benefits in 1 blend with ingredients powered by science for middle-of-the-night sleep support. One tasty fast dissolve tablet provides a lower dose◆ of Melatonin (1 mg) to help you fall asleep and wake up refreshed. Additionally, L-theanine (100 mg) helps relax the mind and GABA (100 mg) helps support a calm mental state before bedtime. These ingredients combined offer a 100% drug-free sleep aid to help you get the rest you need. Read more here about how to improve sleep quality and other ways for how to fall asleep quickly.^†

How much Melatonin can I safely take daily?

Nature Made^® Wellblends™ Back to Sleep™ is meant to be taken upon waking in the middle of the night. It is not recommended to take more than 10 mg of Melatonin per day unless recommended by a physician. Consult a healthcare professional if you are experiencing persistent sleep difficulties. Read more about how much Melatonin you can take daily.

What do L-theanine and GABA help with?

L-theanine is a rare amino acid found in some green and black teas that supports relaxation. GABA acts as a neurotransmitter to help support a calm and relaxed mental state. Nature Made^® Wellblends™ Back To Sleep™ combines these two ingredients to help you relax and calm your mind.^†

Where do Melatonin and L-theanine come from?

Melatonin is a natural hormone produced in the pineal gland in the brain to help regulate sleep/wake cycles, but it can be found in very small amounts in some foods like tart cherries, pistachio nuts, rice, milk, eggs, salmon, and beef. L-theanine is a rare amino acid also found in green and black teas and in the bay bolete mushroom.^†

Can I give this product to my child?

No, this product is not intended for people under age 18. We would recommend discussing any sleep disorders that your child is experiencing with your pediatrician. For children, consider our low-dose Melatonin supplement Kids First^® Sleep.

Are there side effects from taking this product?

Mild side effects may include headaches, dizziness, nausea, vivid dreams, and lack of appetite. Increased heart rate is another reported side effect; if you experience this or other persistent side effects, discontinue use and consult with your healthcare provider.

How long can I take this product?

Nature Made® Wellblends™ Back to Sleep™ is designed for short-term sleep support only. Do not supplement for longer than three months.

Can I take this with other Melatonin products?

We do not recommend taking any other Melatonin-containing products while taking Nature Made^® Wellblends™ Back to Sleep™ without first speaking with your healthcare provider.

This packaging looks different than what I’m used to. Has the formula changed?

Nope! Nature Made Wellblends™ Back To Sleep™ has a new look, but the formula remains the same with the same benefits.^†

How do I take these Melatonin tablets?

Adults, take 1 fast dissolve tablet 30 minutes before bedtime to help fall asleep or upon waking up in the middle of the night. Dissolve in mouth or chew before swallowing. No water necessary. Take at least 4 hours before waking.^†

When does this product expire?

Please refer to the expiration date on the bottle.

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Reviews

Great it works

It’s a great product like all products from biotrust

Im getting mobility back and much decreased pain!

I tried Joint 33x one month at first for my left hip that has had arthritis, bursitis and sciatica. A shot and PT had given some help, but the mobility hadn’t gotten back to anywhere near what it used to be. Chronic pain in my hip, leg and groin continued and my insurance wasn’t willing to do anything else. After one month of this supplement I felRead more about review stating Im getting mobility back and much decreased pain!t better and could move more. I then ordered a 6 pack to continue using this product. Im almost through my second bottle and I cannot believe how much more I can move, even being able to exercise a bit. The pai isn’t totally gone, but went from a pretty consistent 7 to about a 3 most of the time. I will take it and continue to take this supplement! Praise God!

The best I’ve ever had

Great product! I didn’t know until I had to stop taking it for week. Glad I can start using it again. Definitely recommend trying it.

It helps My psoriatic arthritis

It helps My psoriatic arthritis immensely!

I had knee pain for

I had knee pain for years. After first 30 days taking “Joint 33X” I knees almost stopped herd. Now I take it every six months or so and my knees pain completely gone.

SO GLAD TO BE BACK USING THIS PRODUCT!

I have been a follower of BioTrust for a very long time, at least 10 or twelve years. ( But, I am old and could be off by a few years. ). I have use many of their products. One product I started with several years ago was the JOINT33X, and for some reason stopped. I don’t know why I stopped. But, recently I was awarded a product of my choice in a Read more about review stating SO GLAD TO BE BACK USING THIS PRODUCT!

trivia competition about BioTrust. Long story short, I chose JOINT33X. I am so glad I did! Pain of my arthritis disappears a few hours after taking in the morning, but doesn’t last into the night. Can I take it more than once a day? If that is ok, maybe produce a larger size! Anyway, thank you for gifting me the product, I am very happy being part of the BIO TRUST family! Much love, Lyla

These are a must for me These are great! I have tried other joint supplements but never noticed a difference like I have with these. The capsules are easy to swallow, they don’t give me any stomach issues and the have helped reduce the amount of joint stiffness and pain significantly

Help for Arthritic Knee Pain

Since I started using this Joint 33x daily I have much less knee pain. I can walk up and down stairs normally instead of slowly one at a time. I can actually run without having to stop suddenly because of pain. It also has helped to eliminate gluten from my diet to lessen joint pain.

Joint 33 is a game changer

Works well, immediate effect…

ALL I CAN SAY IS

ALL I CAN SAY IS WOW!!! I KNOW IT SAYS TAKE ONE I DO IN THE EARLY MORNING BUT I TAKE ANOTHER AT NIGHT SO IN THE MORING WHEN I WAKE, I GET UP PAIN FREE. I AM ABLE TO CLIMB STAIRS LIKE I SHOULD NOT LEANING AGAINST THE WALL AND GRABBING THE BANISTER AND NOT GOING IS SLOW MOTION. THIS IS THE BEST STUFF I HAVE EVER TRIED THAT REALLY WORKS AND I WILL TERead more about review stating ALL I CAN SAY IS

LL EVERYONE ABOUT IT I AM THINKING OF SENDING A BOTTLE TO MY SISTER TO TRY AS SHE LIKE ME IS IN A LOT OF PAIN AND I NO LONGER HAVE IT AS MY JOINTS ARE WELL OILED. THANK YOU FOR MAKING SUCH AN AWESOME PRODUCT